Are they not holding it while your using it,or just when u move it.
In this movie,the author states on bigger scopes,he has to collimate every time he uses it.
http://www.andysshotglass.com/Collimating.html
Since i built my cheap little hand truck,i have not had to adjust mine the last 3 times i took it out,and had a great pattern when i star tested it.The last time i put the laser on mine,once it was adjusted i equally tightened the other 3 set screws.It seems to be holding fine.
good luck
kevin